Wong, Isaac Kai Jie MBBS^*; Kim, Jin-Hyun MD^†; Rosellini, Isabella MD^‡; Song, Jong Keun MD^§; Lee, Han Earl MD^∥; Yi, Kyu-Ho MD, PhD^¶

Background:
The shape and size of ears significantly influence facial aesthetics. In many Asian cultures, lying ears are not perceived favorably in Asian culture, leading individuals to seek surgical interventions to correct this issue. Also, due to the Ebbinghaus effect, prominent ears create a illusion of a smaller face, which is highly desired in Asians. However, surgeries to create prominent ears are invasive, can involve complications and necessitate a period of recovery. To address this concern, the authors have developed a technique utilizing hyaluronic acid (HA) injections of MAILI range (Sinclair Pharma) to enhance the appearance of lying ears.

Methods:
HA injections were performed at the auriculocephalic sulcus and the helix to increase the cranioauricular angle (CA) and correct lying ears.

Results:
Patients showed improvements in ear prominence. The cranioauricular angle (CAA) and ear projection (EP) increased immediately after the procedure. No serious complications were noted.

Conclusion:
The injection of hyaluronic acid (HA) into the ears successfully addressed the issue of lying ears and enhanced the overall facial profile. In addition, it provided a lifting effect that contributed to a more youthful and refined appearance. This minimally invasive procedure did not necessitate any recovery time, and the results were long-lasting and highly satisfactory.

Gi-Woong Hong, MD, PhD,* Isaac Kai Jie Wong, MBBS,†Jong Keun Song, MD,‡ Jesper Thulesen, MD, PhD,§Ka Fai Wong, MBChB,∥ and Kyu-Ho Yi, MD, PhD¶

Forehead filler injections have become a popular nonsurgical approach to enhance facial aesthetics by correcting volume deficiencies and improving contours. This anatomy-based approach emphasizes the importance of understanding the complex structural components of the forehead, including fat compartments, muscles, and vascular pathways. Proper diagnosis of forehead depressions—categorized as central, bilateral, mixed, or total types—guides targeted treatment strategies using submuscular or subdermal injection planes. Submuscular injections provide structural support, minimizing risks associated with superficial placement, such as uneven distribution and vascular complications. Techniques tailored to specific anatomic features, particularly in East Asian patients who often present with narrower foreheads, ensure natural and balanced results. Fillers used in this paper are Hyaluronic Acid (Maili, Sinclair) and Polycaprolactone (Ellanse, Sinclair). Combining fillers with botulinum toxin injections can address both dynamic and static wrinkles, achieving comprehensive facial rejuvenation while maintaining natural expressions, which is especially true for Polycaprolactone biostimulator fillers. This integrated approach optimizes aesthetic outcomes and enhances patient satisfaction by delivering smooth, contoured, and youthful forehead appearances.

Hong, Gi-Woong MD, PhD^*; Wong, Isaac Kai Jie MD^†; Byungki, Cho MD^‡; Yoon, Song Eun MD^§; Song, Jong Keun MD^‖; Haykal, Diala MD^¶; Wan, Jovian MBChB^#; Kim, Jin-Hyun MD^**; Yi, Kyu-Ho MD, PhD^**,††

Nasolabial folds significantly impact facial appearance and are a common aesthetic concern. This article reviews anatomic considerations and filler injection techniques for treating these folds, with a focus on the Korean population. The dermal filler used in this study is Maili hyaluronic acid filler (Sinclair Pharma), derived from a novel proprietary manufacturing technology known as OxiFree™ technology (Kylane Laboratoires , Switzerland).

The study analyzes various injection techniques, including needle-based and cannula-based approaches, with emphasis on safe and effective practices such as the Fern leaf and Duck walk techniques. A layered injection approach addressing both superficial and deep tissue planes is examined.

Three distinct types of nasolabial folds are identified: those caused by volume deficiency, tissue laxity, and muscular attachments. Each type requires a tailored treatment approach. It is not uncommon to find a combination of 2 of the types together in one person. The study highlights the importance of understanding anatomic variations, particularly the course of the facial artery in the Korean population, for safe injection practices.

A thorough understanding of nasolabial fold anatomy and appropriate treatment strategies is crucial for achieving optimal outcomes in aesthetic medicine. This is especially important for the nasolabial folds, which are highly mobile, and could easily cause misplaced dermal fillers to migrate. Future research on combination intervention techniques, including botulinum toxin, lipolytic agents, and thread-lifting, may further enhance overall treatment efficacy.

Kyu-Ho Yi, Isaac Kai Jie Wong, Jovian Wan

Background
Platysmal bands contribute to neck ageing and lower-face descent. Although botulinum toxin A (BoNT-A) is approved for this indication, conventional whole-muscle dosing requires many superficial injections with attendant risks.
‍
Objective
To develop an anatomically guided protocol that targets motor-dense zones of the platysma, optimizing efficacy while reducing dose and complications.
‍
Methods
Sihler-stained dissections mapped motor versus sensory innervation. Ultrasound-guided injections were performed in 40 patients, delivering 30–60 U BoNT-A per side at 15 sites concentrated in the upper two-thirds of the platysma and along the marginal mandibular border. Outcomes included band severity, jawline definition, adverse events, and cost.
‍
Results
Motor end-plates clustered in the upper platysma; the lower third was largely sensory. Targeted injections produced a ≥ 2-grade reduction in dynamic bands in 92.5% of patients by week 4, maintained through week 12. Mean toxin use fell 35% versus historical whole-muscle protocols; bruising dropped to 5%, with no dysphagia or lower-face weakness. Treatment costs were proportionally lower.
‍
Conclusions
Concentrating BoNT-A in the motor-rich upper platysma under ultrasound guidance maximizes aesthetic improvements while minimizing dose, discomfort and adverse events. This neural distribution-based algorithm offers a safer, more economical alternative to conventional platysmal band treatment.

Koppert, Erik MD^*; Wong, Isaac Kai Jie MD^†; Wan, Jovian MBChB^‡; Yoon, Song Eun MD^§; Song, Jong Keun MD^∥; Kim, Jin-Hyun MD^¶; Yi, Kyu-Ho MD, PhD<sup>¶,#

*Department of Surgery, Epworth Hawthorn and Epworth Eastern Private Hospitals, Melbourne, Victoria, Australia†The Artisan Clinic, Singapore, Singapore‡Medical Research Inc., Wonju, Korea§BRANDNEW Aesthetic Surgery Clinic∥Pixelab Plastic Surgery Clinic¶You and I clinic#Department of Oral Biology, Division of Anatomy and Developmental Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Korea</sup>

Jovian Wan, Benjamin Ascher, Leonie Schelke, Isaac Kai Jie Wong, Peter J. Velthuis, Won Lee, Hee-Jin Kim, Kyu-Ho Yi

First published: 30 June 2025

https://doi.org/10.1111/jocd.70313

Funding: The authors received no specific funding for this work.

The Artisan Clinic, 435 Orchard Road, #20-03, Singapore, Singapore
‍Isaac Kai Jie Wong
‍
‍Wlabel, Seoul, Korea
‍Olena Sydorchuk
‍
‍Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea
‍Kyu-Ho Yi

‍You and I Clinic, Seoul, Korea
‍Kyu-Ho Yi

‍Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea
‍Kyu-Ho Yi

‍The Artisan Clinic, 435 Orchard Road, #20-03, Singapore, 238877, Singapore
‍Isaac Kai Jie Wong

‍Gaddiel Medical Group Limited, Tsim Sha Tsui, Hong Kong, China
‍Ka Fai Wong

‍EverKeen Medical Centre, Hong Kong, China
‍Kar Wai Alvin Lee

Goo, B., Kim, E., Yoon, S.E. et al. Efficacy and Safety of High-Intensity Focused Ultrasound (HIFU) on Reduction of Unwanted Submental Fat in Asian Patients. Aesth Plast Surg (2025). https://doi.org/10.1007/s00266-025-04890-0

Wan, Jovian MBChB^*; Yoon, Song Eun MD^†; Song, Jong-Keun MD^‡; Wong, Isaac Kai Jie MD^§; Kim, Jin-Hyun MD^∥; Yi, Kyu-Ho MD, PhD<sup>∥,¶

*Medical Research Inc., Wonju, Korea†BRANDNEW Aesthetic Surgery Clinic‡Pixelab Plastic Surgery Clinic, Seoul, korea§The Artisan Clinic, Singapore∥You and I Clinic, Seoul, Korea¶Department of Oral Biology, Division of Anatomy and Developmental Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seodaemun-gu, Seoul, KoreaAddress correspondence and reprint requests to Kyu-Ho Yi, MD, Department of Oral Biology, Division of Anatomy and Developmental Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea; E-mail: kyuho90@daum.netJ.W. and K.-H.Y.: conceptualization. J.W.: writing-original draft preparation. J.W., S.E.Y., J.K.S., I.K.J.W., J.-H.K., and K.-H.Y.: writing-review and editing. J.W. and K.-H.Y.: visualization. K.-H.Y.: supervision. All authors have reviewed and approved the article for submission.The authors report no conflicts of interest. This study was conducted in compliance with the principles set forth in the Declaration of Helsinki.Supplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal’s website, www.jcraniofacialsurgery.com.The Journal of Craniofacial Surgery ():10.1097/SCS.0000000000011459, May 5, 2025. | DOI: 10.1097/SCS.0000000000011459</sup>

By Isaac Kai Jie Wong ¹, Jovian Wan ², Kyu-Ho Yi <sup>3 4

‍</sup>Affiliations
‍¹The Artisan Clinic, Singapore.
‍²Medical Research Inc., Wonju.
‍³Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seodaemun-gu.
‍⁴You and I Clinic (Mokdong), Seoul, Korea.

By Wan, Jovian MBChB^*; Yoon, Song Eun MD^†; Pamela, Ruri MD^‡; Kai Jie Wong, Isaac MD^§; Vitale, Massimo MD^∥; Cartier, Hugues MD^¶; Garson, Sebastien MD^#; Yi, Kyu-Ho MD, PhD^**,††

*Medical Research Inc., Wonju
†BRANDNEW Aesthetic Surgery Clinic, Seoul, Korea
‡CELV Dermatology Clinic, Jakarta, Indonesia
§The Artisan Clinic, Singapore
∥Private Practice, Bologna, Italy
¶Centre Médical Saint Jean, Arras, France
#Cabinet Médical, Senlis, France
**Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry
††You and I Clinic, Seoul, Korea

By Isaac Wong Kai Jie ^1, Kar Wai Alvin Lee ², Song Eun Yoon ³, Jong Keun Song ⁴, Lisa Kwin Wah Chan ⁵, Cheuk Hung Lee ⁶, Eunji Jeong <sup>7

1</sup> The Artisan Clinic, Singapore
² EverKeen Medical Centre, Hong Kong
³ Brandnew Aesthetic Surgery Clinic, Seoul, Republic of Korea
⁴ Pixelab Plastic Surgery Clinic, Seoul, Republic of Korea
⁵ College of Medicine, Central Michigan University, Saginaw, MI, USA
⁶ You & I Clinic, Seoul, Republic of Korea
⁷ Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea* Author to whom correspondence should be addressed.

By Isaac Wong Kai Jie ^1, Kar Wai Alvin Lee ², Song Eun Yoon ³, Jong Keun Song ⁴, Lisa Kwin Wah Chan ⁵, Cheuk Hung Lee ⁶, Eunji Jeong <sup>7

1</sup> The Artisan Clinic, Singapore
² EverKeen Medical Centre, Hong Kong
³ Brandnew Aesthetic Surgery Clinic, Seoul, Republic of Korea
⁴ Pixelab Plastic Surgery Clinic, Seoul, Republic of Korea
⁵ College of Medicine, Central Michigan University, Saginaw, MI, USA
⁶ You & I Clinic, Seoul, Republic of Korea
⁷ Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea* Author to whom correspondence should be addressed.